{"id":3133,"date":"2024-11-15T11:33:59","date_gmt":"2024-11-15T03:33:59","guid":{"rendered":"\/\/www.yitiaoweiba.com\/%e5%90%9b%e5%ae%9e%e7%94%9f%e7%89%a9%e7%89%b9%e7%91%9e%e6%99%ae%e5%88%a9%e5%8d%95%e6%8a%97extentorch%e7%a0%94%e7%a9%b6%e5%9c%a8%e5%9b%bd%e9%99%85%e6%9d%83%e5%a8%81%e6%9c%9f%e5%88%8ajama%e5%ad%90\/"},"modified":"2024-11-18T11:38:51","modified_gmt":"2024-11-18T03:38:51","slug":"%e5%90%9b%e5%ae%9e%e7%94%9f%e7%89%a9%e7%89%b9%e7%91%9e%e6%99%ae%e5%88%a9%e5%8d%95%e6%8a%97extentorch%e7%a0%94%e7%a9%b6%e5%9c%a8%e5%9b%bd%e9%99%85%e6%9d%83%e5%a8%81%e6%9c%9f%e5%88%8ajama%e5%ad%90","status":"publish","type":"post","link":"\/\/www.yitiaoweiba.com\/zh-hant\/%e5%90%9b%e5%ae%9e%e7%94%9f%e7%89%a9%e7%89%b9%e7%91%9e%e6%99%ae%e5%88%a9%e5%8d%95%e6%8a%97extentorch%e7%a0%94%e7%a9%b6%e5%9c%a8%e5%9b%bd%e9%99%85%e6%9d%83%e5%a8%81%e6%9c%9f%e5%88%8ajama%e5%ad%90\/","title":{"rendered":"\u541b\u5be6\u751f\u7269\u7279\u745e\u666e\u5229\u55ae\u6297EXTENTORCH\u7814\u7a76\u5728\u570b\u969b\u6b0a\u5a01\u671f\u520aJAMA\u5b50\u520a\u767c\u8868"},"content":{"rendered":"\n<p>\u7576\u5730\u6642\u959311\u670814\u65e5\uff0c\u7531\u5409\u6797\u7701\u816b\u7624\u91ab\u9662\u7a0b\u7a4e\u6559\u6388\u727d\u982d\u958b\u5c55\u7684\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u5316\u7642\u4e00\u7dda\u6cbb\u7642\u5ee3\u6cdb\u671f\u5c0f\u7d30\u80de\u80ba\u764c (ES-SCLC) \u7684III\u671fEXTENTORCH\u7814\u7a76\u7d50\u679c\u767c\u8868\u5728\u570b\u969b\u816b\u7624\u5b78\u9802\u7d1a\u671f\u520a\u300a\u7f8e\u570b\u91ab\u5b78\u6703\u96dc\u8a8c\u00b7\u816b\u7624\u5b78\u300b (<em>JAMA Oncology<\/em>\uff0cIF<sub>2023<\/sub>=22.5\uff09\uff0c\u70baES-SCLC\u4e00\u7dda\u514d\u75ab\u6cbb\u7642\u518d\u6dfb\u91cd\u78c5\u5faa\u8b49\u91ab\u5b78\u8b49\u64da\u3002\u7a0b\u7a4e\u6559\u6388\u70ba\u672c\u6587\u7684\u7b2c\u4e00\u4f5c\u8005\u548c\u901a\u8a0a\u4f5c\u8005\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"3011\" height=\"1698\" src=\"\/\/www.yitiaoweiba.com\/wp-content\/uploads\/2024\/11\/\u63d2\u56fe.png\" alt=\"\" class=\"wp-image-3128\"\/><\/figure>\n\n\n\n<p>EXTENTORCH\u7814\u7a76\uff08NCT04012606\uff09\u662f\u4e00\u9805\u591a\u4e2d\u5fc3\u3001\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u6bd4\u8f03\u7279\u745e\u666e\u5229\u55ae\u6297\u6216\u5b89\u6170\u5291\u806f\u5408\u4f9d\u8a17\u6cca\u82f7\u53ca\u9251\u985e\u4e00\u7dda\u6cbb\u7642ES-SCLC\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002<\/p>\n\n\n\n<p>EXTENTORCH\u7814\u7a76\u4e3b\u8981\u7814\u7a76\u8005\uff0c<strong>\u5409\u6797\u7701\u816b\u7624\u91ab\u9662\u7a0b\u7a4e\u6559\u6388<\/strong>\u8868\u793a\uff1a\u201cEXTENTORCH\u7814\u7a76\u4f5c\u70baES-SCLC\u9818\u57df\u5168\u7403\u9996\u500b\u6210\u529f\u9054\u5230\u9810\u8a2d\u96d9\u4e3b\u8981\u7814\u7a76\u7d42\u9ede\u967d\u6027\u7d50\u679c\u7684\u6297PD-1\u55ae\u6297\u7684\u2162\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u662fES-SCLC\u6cbb\u7642\u7684\u53c8\u4e00\u6b21\u95dc\u9375\u7a81\u7834\u3002 \u8a66\u9a57\u7d441\u5e74PFS\u7387\u63d0\u5347\u8fd14\u500d\uff0c\u6240\u6709\u4e9e\u7d44\u60a3\u8005\u5747\u6709\u7372\u76ca\uff0c\u4e3b\u8981\u7d42\u9ede\u4e4b\u4e00\u7684OS\u53d6\u5f97\u967d\u6027\u7d50\u679c\uff0c\u6210\u529f\u901a\u904e\u4e86\u81e8\u5e8a\u201c\u91d1\u6a19\u6e96\u201d\u7684\u8003\u6838\uff0c\u70ba\u60a3\u8005\u5e36\u4f86\u78ba\u5207\u751f\u5b58\u7372\u76ca\u3002\u672c\u6b21EXTENTORCH\u7814\u7a76\u898b\u520a\u4e0d\u50c5\u516c\u4f48\u4e86\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u5316\u7642\u4e00\u7dda\u6cbb\u7642ES-SCLC\u7684\u7642\u6548\u8cc7\u6599\uff0c\u66f4\u91cd\u8981\u7684\u662f\uff0c\u9019\u9805\u7814\u7a76\u9032\u884c\u4e86\u5206\u5b50\u5c64\u9762\u7684\u63a2\u7d22\uff0c\u5c0d\u7be9\u9078\u63a5\u53d7\u514d\u75ab\u6cbb\u7642\u7684\u60a3\u8005\u5177\u6709\u91cd\u8981\u7684\u6307\u5c0e\u610f\u7fa9\u3002\u201d<\/p>\n\n\n\n<p>2023\u5e745\u6708\uff0cEXTENTORCH\u7814\u7a76\u4e3b\u8981\u7d42\u9ede\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u548c\u7e3d\u751f\u5b58\u671f\uff08OS\uff09\u5747\u9054\u5230\u65b9\u6848\u9810\u8a2d\u7684\u512a\u6548\u908a\u754c\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u7531\u6b64\u6210\u70ba\u5168\u7403\u9996\u500b\u5728ES-SCLC\u4e00\u7dda\u6cbb\u7642III\u671f\u7814\u7a76\u4e2d\u53d6\u5f97\u9810\u8a2d\u96d9\u91cd\u4e3b\u8981\u7d42\u9ede\u967d\u6027\u7d50\u679c\u7684PD-1\u6291\u5236\u5291\u3002<\/p>\n\n\n\n<p>2024\u5e746\u6708\uff0c\u57fa\u65bc\u8a72\u7814\u7a76\u7684\u7a4d\u6975\u7d50\u679c\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u7372\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u6b63\u5f0f\u6279\u51c6\u806f\u5408\u4f9d\u8a17\u6cca\u82f7\u548c\u9251\u985e\u7528\u65bcES-SCLC\u4e00\u7dda\u6cbb\u7642\uff0c\u4e26\u7372\u4e2d\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08CSCO\uff09\u5169\u5927\u6307\u5357\u63a8\u85a6\u70baES-SCLC\u4e00\u7dda\u6cbb\u7642\u512a\u9078\u65b9\u6848\uff0c\u70ba\u4e2d\u570bES-SCLC\u60a3\u8005\u63d0\u4f9b\u4e86\u6cbb\u7642\u65b0\u9078\u64c7\u3002<\/p>\n\n\n\n<p>\u6b64\u524d\uff0cEXTENTORCH\u7814\u7a76\u4ee5\u53e3\u982d\u5831\u544a\u7684\u5f62\u5f0f\u57282023\u5e74ESMO\u5927\u6703\u4e0a\u9996\u6b21\u516c\u4f48\u4e86\u7814\u7a76\u8cc7\u6599\uff0c\u6b64\u6b21\u5168\u6587\u767c\u8868\u65bc\u570b\u969b\u671f\u520a\uff0c\u5f70\u986f\u4e86\u570b\u969b\u5b78\u8005\u5c0d\u9019\u9805\u7814\u7a76\u53ca\u7279\u745e\u666e\u5229\u55ae\u6297\u7684\u80af\u5b9a\uff0c\u7d50\u679c\u986f\u793a\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u8207\u55ae\u7d14\u5316\u7642\u76f8\u6bd4\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u5316\u7642\u986f\u8457\u6539\u5584\u60a3\u8005PFS\u548cOS\uff0c\u5c07\u75be\u75c5\u9032\u5c55\u6216\u6b7b\u4ea1\u98a8\u96aa\u964d\u4f4e33%\uff08HR=0.67\uff1b95% CI\uff0c 0.54-0.82\uff09\uff0c\u6b7b\u4ea1\u98a8\u96aa\u964d\u4f4e\u4e8620%\uff08HR=0.80\uff1b95% CI\uff0c 0.65-0.98\uff09\u3002\u4e9e\u7d44\u5206\u6790\u986f\u793a\uff0c\u6240\u6709\u95dc\u9375\u4e9e\u7d44\u5747\u986f\u793a\u51fa\u4e00\u81f4\u7684PFS\u548cOS\u7372\u76ca\u3002<\/li>\n\n\n\n<li>\u751f\u7269\u6a19\u8a8c\u7269\u63a2\u7d22\u5206\u6790\u986f\u793a\uff0c\u5728\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u5316\u7642\u7d44\u4e2d\uff0c\u5177\u6709\u4f4e\u816b\u7624\u5167\u7570\u8cea\u6027\uff08ITH\uff09\uff0c<em>HLA-A11<sup>+<\/sup> HLA-B62<sup>&#8211;<\/sup><\/em>\u55ae\u500d\u578b\uff0c<em>KMT2D 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class=\"wp-block-heading\"><em>1. \u672c\u6750\u6599\u65e8\u5728\u50b3\u905e\u524d\u6cbf\u8cc7\u8a0a\uff0c\u7121\u610f\u5411\u60a8\u505a\u4efb\u4f55\u7522\u54c1\u7684\u63a8\u5ee3\uff0c\u4e0d\u4f5c\u70ba\u81e8\u5e8a\u7528\u85e5\u6307\u5c0e\u3002<\/em><\/h6>\n\n\n\n<h6 class=\"wp-block-heading\"><em>2. 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