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\u9f3b\u54bd\u764c\u662f\u4e00\u79cd\u539f\u53d1\u4e8e\u9f3b\u54bd\u90e8\u9ecf\u819c\u4e0a\u76ae\u7684\u6076\u6027\u80bf\u7624\uff0c\u662f\u5e38\u89c1\u7684\u5934\u9888\u90e8\u80bf\u7624\u4e4b\u4e00\u3002\u636e\u7edf\u8ba1\uff0c2020\u5e74\u5168\u7403\u9f3b\u54bd\u764c\u65b0\u53d1\u75c5\u4f8b\u6570\u8d85\u8fc713\u4e07[1]<\/a>\uff0c\u5176\u4e2d\u8fd1\u534a\u6570\u75c5\u4f8b\u5728\u4e2d\u56fd [2]<\/a>\u3002\u4e2d\u56fd\u5357\u65b9\uff08\u5982\u5e7f\u4e1c\u3001\u5e7f\u897f\uff09\u548c\u4e1c\u5357\u4e9a\u5730\u533a\u9ad8\u53d1 [3]<\/a>\u3002\u5bf9\u4e8e\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\uff0c\u76ee\u524d\u7684\u6cbb\u7597\u624b\u6bb5\u6709\u9650\uff0c\u4e00\u7ebf\u6807\u51c6\u6cbb\u7597\u65b9\u6848\u662f\u4ee5\u94c2\u7c7b\u4e3a\u57fa\u7840\u7684\u4e24\u836f\u8054\u5408\u5316\u7597\uff0c\u4f46\u6cbb\u7597\u540e\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u65f6\u95f4\u4ec5\u67097\u4e2a\u6708\u5de6\u53f3 [4]<\/a>\u3002<\/p>\n\n\n\n

\u4e2d\u5c71\u5927\u5b66\u80bf\u7624\u9632\u6cbb\u4e2d\u5fc3\u5f90\u745e\u534e\u6559\u6388\u56e2\u961f\u4e0e\u672c\u571f\u521b\u65b0\u836f\u4f01\u541b\u5b9e\u751f\u7269\u5408\u4f5c\uff0c\u81ea2016\u5e74\u8d77\u63a2\u7d22\u65b0\u5174\u514d\u75ab\u7597\u6cd5\u4e0e\u4f20\u7edf\u5316\u7597\u76f8\u7ed3\u5408\u7684\u521b\u65b0\u578b\u4e34\u5e8a\u65b9\u6848\uff0c\u5f00\u5c55\u540e\u7ebf\u81f3\u4e00\u7ebf\u6cbb\u7597\u201c\u5168\u7ebf\u8d2f\u7a7f\u201d\u7684\u4e34\u5e8a\u5e03\u5c40\u3002\u4eceIb\/II\u671f\u7684\u5c0f\u6837\u672c\u91cf\u63a2\u7d22\u6027\u7814\u7a76\u3001II\u671f\u514d\u75ab\u5355\u836f\u4e8c\u7ebf\u53ca\u540e\u7ebf\u6cbb\u7597\u7684POLARIS-02\u7814\u7a76\uff0c\u518d\u5230\u9996\u521b\u5168\u7403\u89c4\u6a21\u6700\u5927\u7684\u56fd\u9645\u591a\u4e2d\u5fc3\u201c\u514d\u75ab\u6cbb\u7597+\u5316\u7597\u201d\u4e00\u7ebf\u6cbb\u7597\u7684JUPITER-02\u7814\u7a76\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\uff08\u62d3\u76ca^{\u00ae<\/sup>\uff09\u5728\u9f3b\u54bd\u764c\u6cbb\u7597\u9886\u57df\u53d6\u5f97\u4e86\u624e\u5b9e\u7684\u5faa\u8bc1\u533b\u5b66\u8bc1\u636e\u3002<\/p>\n\n\n\n}

\u6b64\u6b21\u65b0\u9002\u5e94\u75c7\u7684\u83b7\u6279\u57fa\u4e8eJUPITER-02\u7814\u7a76\uff08NCT03581786\uff09\uff0c\u662f\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u56fd\u9645\u591a\u4e2d\u5fc3III\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u7531\u5f90\u745e\u534e\u6559\u6388<\/strong>\u62c5\u4efb\u4e3b\u8981\u7814\u7a76\u8005\uff0c\u5728\u4e2d\u56fd\u3001\u7f8e\u56fd\u4e24\u5730\u540c\u65f6\u6ce8\u518c\u3002\u81ea2018\u5e7411\u6708\u81f32019\u5e7410\u6708\uff0cJUPITER-02\u7814\u7a76\u5728\u4e2d\u56fd\u5927\u9646\u3001\u4e2d\u56fd\u53f0\u6e7e\u3001\u65b0\u52a0\u5761\u768435\u5bb6\u7814\u7a76\u4e2d\u5fc3\u5171\u7eb3\u5165289\u4f8b\u672a\u63a5\u53d7\u8fc7\u5316\u7597\u7684\u590d\u53d1\/\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\u60a3\u8005\u3002<\/p>\n\n\n\n

\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u5355\u7eaf\u5316\u7597\u76f8\u6bd4\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u5409\u897f\u4ed6\u6ee8\u548c\u987a\u94c2\uff08GP\u5316\u7597\uff09\u4e00\u7ebf\u6cbb\u7597\u590d\u53d1\/\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\u53ef\u83b7\u5f97\u66f4\u4f18\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3001\u66f4\u9ad8\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u548c\u66f4\u957f\u7684\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08DoR\uff09\uff0c\u5b89\u5168\u6027\u53ef\u7ba1\u7406\uff0c\u4e14\u65e0\u8bba\u60a3\u8005PD-L1\u8868\u8fbe\u5982\u4f55\uff0c\u5747\u53ef\u83b7\u76ca\u3002\u622a\u81f3\u671f\u4e2d\u5206\u6790\u65e5\uff082020\u5e745\u670830\u65e5\uff09\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u5316\u7597\u7ec4\u7684\u4e2d\u4f4dPFS\u8fbe\u523011.7\u4e2a\u6708\uff0c\u6bd4\u5b89\u6170\u5242\u8054\u5408\u5316\u7597\u7ec4\u5ef6\u957f3.7\u4e2a\u6708\uff08HR=0.52 [95\uff05CI\uff1a0.36-0.74]\uff0c\u53cc\u4fa7p=0.0003\uff09\uff1b\u5c06\u8fd1\u4e00\u534a\u60a3\u8005\u8d85\u8fc7\u4e00\u5e74\u8fd8\u6ca1\u6709\u53d1\u751f\u75be\u75c5\u8fdb\u5c55\uff0c\u6bd4\u5b89\u6170\u5242\u7ec4\u591a21.5%\uff0c\u4ee3\u8868\u6709\u66f4\u591a\u60a3\u8005\u83b7\u76ca\uff1bORR\u4e3a77.4% vs 66.4%\uff08P=0.033\uff09\uff0c\u4e2d\u4f4dDoR\u4e3a10.0 vs 5.7\u4e2a\u6708\uff08HR = 0.50 [95\uff05CI\uff1a0.33-0.78]\uff09\uff0c\u6bd4\u5b89\u6170\u5242\u7ec4\u5ef6\u957f\u8fd11\u500d\uff1b\u76ee\u524d\u4e2d\u4f4d\u603b\u751f\u5b58\uff08OS\uff09\u4ecd\u672a\u6210\u719f\uff0c\u4e0d\u8fc7\u5df2\u89c2\u5bdf\u5230\u7279\u745e\u666e\u5229\u5355\u6297\u7ec4\u603b\u751f\u5b58\u7684\u83b7\u76ca\u8d8b\u52bf\uff0c\u5176\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e\u4e8640%\u3002<\/p>\n\n\n\n

\u4f5c\u4e3a\u8fc4\u4eca\u4e3a\u6b62\u5168\u7403\u8303\u56f4\u5185\u89c4\u6a21\u6700\u5927\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u8054\u5408\u5316\u7597\u4e00\u7ebf\u6cbb\u7597\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\u7684III\u671f\u4e34\u5e8a\u7814\u7a76\uff0cJUPITER-02\u7814\u7a76\u591a\u6b21\u83b7\u5f97\u56fd\u9645\u5b66\u754c\u9ad8\u5ea6\u5173\u6ce8\uff0c\u66fe\u4ee5\u201c\u91cd\u78c5\u7814\u7a76\u6458\u8981\u201d\u5f62\u5f0f\uff08#LBA2\uff09\u5165\u9009\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u5e74\u4f1a\uff08ASCO 2021\uff09\u5168\u4f53\u5927\u4f1a\uff0c\u5e76\u57282021\u5e749\u6708\u4ee5\u5c01\u9762\u63a8\u8350\u5f62\u5f0f\u520a\u767b\u5728SCI\u5f71\u54cd\u56e0\u5b50\u6392\u540d\u524d20\u4f4d\u7684\u56fd\u9645\u9876\u5c16\u671f\u520a\u300a\u81ea\u7136-\u533b\u5b66\u300b\u6742\u5fd7\uff08Nature Medicine<\/em>\uff0c\u5f71\u54cd\u56e0\u5b50\uff1a53.440\uff09\uff0c\u8fd9\u4e5f\u662f\u300a\u81ea\u7136-\u533b\u5b66\u300b\u521b\u520a26\u5e74\u6765\u9996\u6b21\u5728\u5c01\u9762\u4e0a\u63a8\u8350\u4e2d\u56fd\u521b\u65b0\u836f\u7269\u7814\u7a76\u3002<\/p>\n\n\n\n

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<\/p>\n\n\n\n

\u53c2\u8003\u6587\u732e\uff1a<\/h5>\n\n\n\n[1]<\/a> https:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/4-Nasopharynx-fact-sheet.pdf.<\/h5>\n\n\n\n
[2]<\/a> https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/160-china-fact-sheets.pdf.<\/h5>\n\n\n\n
[3]<\/a> Chen YP, et al. Lancet 2019.394:64-80,<\/h5>\n\n\n\n
[4]<\/a> https:\/\/ascopubs.org\/doi\/abs\/10.1200\/JCO.2020.38.15_suppl.6521.<\/h5>\n\n\n\n\n\n
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